Synthesis of 3,4-Dihydropyridin-2-ones via Domino Reaction under Phase Transfer Catalysis Conditions

3,4-dihydropyridin-2-ones are of considerable importance due to the large number these core structures exhibiting a diverse array biological and pharmacological activities. The Michael-type addition 1,3-dithiane-2-carbothioates α,β-unsaturated N-tosyl imines, followed by intramolecular annulation driven sulfur leaving group, provides practical reaction cascade for synthesis variety substituted 3,4-dihydropyridin-2-ones. In this work, was carried out under solid–liquid phase transfer catalysis (SL-PTC) conditions at room temperature, in short times presence cheap Bu4N+HSO4– solid KOH. new PTC method exhibited adequate functional group tolerance, proving be green reliable easy scale up furnish rapid access after desulfurization from simple, readily available starting materials.